Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors
نویسندگان
چکیده
منابع مشابه
Glycogen Synthase Kinase 3 Is a Natural Activator of Mitogen-activated Protein Kinase/Extracellular Signal-regulated
Glycogen synthase kinase 3 (GSK3 ) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and insulin response. GSK3 has now been shown to induce activation of the mitogen-activated protein kinase kinase kinase MEKK1 and thereby to promote signaling by the stressactivated protein kinase pathway. GSK3 -binding protein blocked the activation of ...
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The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α. p38α was activated and formed a disulfide-bound heterodimer with MAP2K3 (MKK3) in rat cardiomyocytes and isolat...
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Recombinant muscle GYS1 (glycogen synthase 1) and recombinant liver GYS2 were phosphorylated by recombinant AMPK (AMP-activated protein kinase) in a time-dependent manner and to a similar stoichiometry. The phosphorylation site in GYS2 was identified as Ser7, which lies in a favourable consensus for phosphorylation by AMPK. Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by d...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2019
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2019.04.035